Macasaet M, Brigati D, Boyce J, Nicastri A, Waxman M, Nelson J, Fruchter R
Am J Obstet Gynecol. 1980 Nov 1;138(5):557-63. doi: 10.1016/0002-9378(80)90286-0.
The extent and location of residual disease after radiotherapy in 91 patients with early invasive endometrial carcinoma was related to tumor grade, clinical stage, and outcome. In 20% the grade (according to the International Federation of Gynecology and Obstetrics) differed in curettage and hysterectomy specimens. In at least 12% the clinical stage was unreliable. Death from endometrial carcinoma was significantly more frequent in patients with residual disease after radiotherapy than in those without residual disease. The poorest prognostic features were blood vesel invasion in the myometrium, irrespective of depth of invasion, and residual disease outside the uterus. Treatment of endometrial carcinoma should be based on accurate knowledge or prognostic features determined by initial surgery.
91例早期浸润性子宫内膜癌患者放疗后残留病灶的范围和位置与肿瘤分级、临床分期及预后相关。20%的患者（根据国际妇产科联合会标准）刮宫标本和子宫切除标本的分级不同。至少12%的患者临床分期不可靠。放疗后有残留病灶的患者死于子宫内膜癌的频率显著高于无残留病灶的患者。最不利的预后特征是肌层血管浸润，无论浸润深度如何，以及子宫外残留病灶。子宫内膜癌的治疗应基于对初始手术确定的预后特征的准确了解。
