Pichlmayr I, Lips U
Anaesthesist. 1980 May;29(5):254-60.
Changes of EEG and CEEG have been studied in two groups of patients premedicated with pethidine-promethazine (dosage: 50 mg/25 mg). The study group A consisted of patients whose age ranged from 20 to 50 years; in study group B the patients age was above 70 years. Continous EEG and CEEG observation ranged from 15 minutes to several hours in a few patients. Changes in clinical behaviour were recorded. Blood pressure - pulserate - measurements were taken at regular intervals. The base line electroencephalogram of thirteen patients was normal. One dialysis-patient of group A and two old patients of group B showed deviations from normal. Characteristic changes in the electroencephalogram after the tested premedication were a decline of alpha amplitude or in primarily abnormal electroencephalographic recordings a narrowing of the frequency band in higher parts, and additionally and increase of delta/theta-activity. These changes lasted several hours. In good correlation to these findings were the clinical effects of sedation and sleep. Side effects were not seen. Remarkable changes of blood pressure and pulserate were not observed.
对两组预先使用哌替啶 - 异丙嗪（剂量：50毫克/25毫克）进行预处理的患者的脑电图（EEG）和动态脑电图（CEEG）变化进行了研究。研究组A由年龄在20至50岁之间的患者组成；研究组B的患者年龄在70岁以上。少数患者的连续脑电图和动态脑电图观察持续了15分钟至数小时。记录了临床行为的变化。定期测量血压和脉搏率。13名患者的基线脑电图正常。A组的一名透析患者和B组的两名老年患者显示出与正常情况的偏差。经测试的预处理后脑电图的特征性变化是α波幅下降，或者在原发性异常脑电图记录中，较高频段的频带变窄，此外还有δ/θ活动增加。这些变化持续了几个小时。与这些发现密切相关的是镇静和睡眠的临床效果。未观察到副作用。未观察到血压和脉搏率的显著变化。
