Larsen R, Turner E, Radke J
Anaesthesist. 1980 May;29(5):282-8.
22 patients with severe preeclampsia-eclampsia were treated in our Intensive Care Unit from 1972 to 1978. Control of convulsions was achieved by diazepam, diphenylhydantoin and phenobarbital. In 11 comatose patients brain monitoring was carried out by frequent neurological examination and use of computerized x-ray tomography; aspiration of gastric contents was prevented by nasotracheal intubation. Brain oedema therapy included controlled hyperventilation, steroids and mannitol (7 patients). 10 patients with respiratory failure (due to pulmonary oedema, "shock lung" or aspiration pneumonitis) were treated by mechanical ventilation. Diastolic blood pressure above 100 mm Hg was reduced by hydralazine. Diuresis was induced by normalization of hypovolaemia with albumin and plasma expanders. Six patients died (27%); main causes of death included intracerebral haemorrhage, brain oedema, heart failure, acute pulmonary thromboembolism and bleeding from DIC.
1972年至1978年期间，我们的重症监护病房收治了22例重度子痫前期-子痫患者。通过地西泮、苯妥英钠和苯巴比妥控制惊厥。11例昏迷患者通过频繁的神经学检查和计算机断层扫描进行脑监测；通过鼻气管插管防止胃内容物误吸。脑水肿治疗包括控制性过度通气、类固醇和甘露醇（7例患者）。10例呼吸衰竭患者（由于肺水肿、“休克肺”或吸入性肺炎）接受了机械通气治疗。通过肼屈嗪降低舒张压至100 mmHg以上。通过白蛋白和血浆扩容剂使血容量正常化来诱导利尿。6例患者死亡（27%）；主要死亡原因包括脑出血、脑水肿、心力衰竭、急性肺血栓栓塞和弥散性血管内凝血出血。
