Halberg F, Nelson W
Adv Exp Med Biol. 1978;108:5-56. doi: 10.1007/978-1-4757-4460-6_2.
Chronobiologic facts, concepts and methods are relevant to gerontology and geriatrics. Circadian and other rhythms are prominent sources of predictable variation requiring a reassessment of the "normal range" at all ages. Changes in the characteristics (e.g., the amplitude) of these rhythms during aging emphasize the need for careful evaluation of time dependency in research and clinical practice. Manipulation of periodic environmental factors that synchronize circadian rhythms can affect lifespans in plants and animals, further supporting the suggestion of an interaction between rhythms and senescence.
