Kimzey S L, Greenberg S D, Baky A A, Winkler D G
Anal Quant Cytol. 1980 Sep;2(3):186-94.
Atypical bronchial epithelial cells from the sputum of male cigarette smokers were digitized by scanning microphotometry and analyzed by computerized image analysis techniques. A set of specific analytic features based on cell morphology was extracted and combined mathematically to be expressed as a single number (Atypia Status Index). This index represented the stages of the cellular atypia (squamous metaplasia; mild, moderate or severe atypia; or carcinoma) quantiatively as a single number varying between 0.0 and 5.5 The Atypia Status Index for each cell correlated highly (94% to 99%) with visual cytopathologic classification. The distributions of cells according to their indices were profiled for patients at various stages of carcinogenesis and used to classify patients relative to their degree of cell atypia. These results compared favorable to those of the clinical evaluation.
对男性吸烟者痰液中的非典型支气管上皮细胞进行扫描显微光度测定数字化处理，并采用计算机图像分析技术进行分析。基于细胞形态学提取了一组特定的分析特征，并进行数学组合，以表示为一个单一数字（非典型状态指数）。该指数将细胞非典型阶段（鳞状化生；轻度、中度或重度非典型；或癌）定量表示为一个介于0.0至5.5之间的单一数字。每个细胞的非典型状态指数与视觉细胞病理学分类高度相关（94%至99%）。根据指数对处于致癌不同阶段患者的细胞分布进行了剖析，并用于根据细胞非典型程度对患者进行分类。这些结果与临床评估结果相比具有优势。
