Paraf A, Karsenti P, Kemeny F, Richard P
Ann Med Interne (Paris). 1980;131(4):235-8.
Five patients who manifested an association between chronic liver disease and lymphoma are reported by the authors. Lymphoma developed long after the presence of liver disease or was discovered simultaneously in the five cases. A review of the available literature yielded a total of thirteen similar cases. Several mechanisms may be operative in the pathogenesis of this association: presence of HBs Ag, chronic antigenic stimulation, decrease in cellular immunity, and immunosuppressive therapy.
作者报告了5例表现出慢性肝病与淋巴瘤之间存在关联的患者。在这5例病例中，淋巴瘤在肝病出现很久之后才发生，或者是同时被发现的。对现有文献的回顾共发现了13例类似病例。这种关联的发病机制可能涉及几种机制：乙肝表面抗原的存在、慢性抗原刺激、细胞免疫降低以及免疫抑制治疗。
