Greco A V, Porcelli G, Magalhaes J F, Altomonte L
Agents Actions. 1978 Dec;8(6):572-5. doi: 10.1007/BF01998885.
Many factors are to be considered in maintaining normal blood pressure. Authors study the behavior of urinary kallikrein (U.K.) and plasma dopamine-beta-hydroxylase (DBH) activity in various forms of hypertension. The values of U.K. excretion in normals were 20.5 +/- 1.8 E.U./24 h. In essential hypertensive patients (9.4 +/- 2.0 E.U./24 h) U.K. decreased, while in secondary hypertension it was significantly higher (33.8 +/- 3.0 E.U./24 h). Plasma DBH activity in essential hypertensive patients (17.72 +/- 2.33 I.U./ml) was similar to controls (20.22 +/- 1.39 I.U./ml); in secondary hypertension the mean values of plasma DBH were decreased (12.31 +/- 2.55 I.U./ml). No correlation between U.K. and plasma DBH activity was observed in normals and in various forms of hypertensive patients. U.K. seems a more reliable factor than plasma DBH in defining the different types of hypertension.
维持正常血压需要考虑许多因素。作者研究了尿激肽释放酶（U.K.）的行为以及血浆多巴胺-β-羟化酶（DBH）活性在各种高血压类型中的情况。正常人尿激肽释放酶的排泄值为20.5±1.8国际单位/24小时。原发性高血压患者的尿激肽释放酶排泄值降低（9.4±2.0国际单位/24小时），而继发性高血压患者的排泄值显著升高（33.8±3.0国际单位/24小时）。原发性高血压患者的血浆DBH活性（17.72±2.33国际单位/毫升）与对照组（20.22±1.39国际单位/毫升）相似；继发性高血压患者血浆DBH的平均值降低（12.31±2.55国际单位/毫升）。在正常人和各种高血压患者中，未观察到尿激肽释放酶与血浆DBH活性之间存在相关性。在区分不同类型的高血压方面，尿激肽释放酶似乎比血浆DBH更可靠。
