[Antibiotic sensitivity of the bacteria persisting in the gastric and duodenal mucosa of peptic ulcer patients].

Sensitivity of 210 strains of aerobic microbes isolated from the deep layers of the gastric and duodenal mucosa of 80 patients with peptic ulcers was studied with respect to benzylpenicillin, ampicillin, ampiox, methicillin, dicloxacillin, tetracycline, streptomycin, monomycin, neomycin and gentamicin. All strains of 6 streptococcal species, 2 staphylococcal species and pseudodiphtheria bacilli proved to be highly sensitive to ampicillin, ampiox, methicillin and dicloxacillin. Ampicillin had the most pronounced bacteriostatic and bactericidal effects on all cutures, except 7 strains of pseudodiphtheria bacilli. It is recommended to carry out clinical trials of ampicillin with respect to its antimicrobial effect in preoperative sanation of the gastric and duodenal mucosa of patients with peptic ulcers for prevention of postresection gastritis and anastomositis.