Ginks W R, Redwood D R
Br Heart J. 1980 Sep;44(3):259-64. doi: 10.1136/hrt.44.3.259.
The administration of vasodilator drugs has been shown to have beneficial effects at rest in patients with acute or chronic heart failure. To determine the efficacy of hydralazine during exercise, 10 severely symptomatic patients with chronic left ventricular failure from diffuse coronary disease or cardiomyopathy were studied at rest and during upright exercise on a bicycle ergometer. All patients were already receiving optimal treatment with digitalis and diuretics. At rest treatment with hydralazine resulted in a fall in both mean arterial and pulmonary wedge pressure. There was a 50 per cent reduction in systemic vascular resistance compared with pretreatment measurements and there was an equally impressive increase in stroke volume index. During exertion the changes noted at rest were sustained though occurred to a lesser degree; thus there was a 20 per cent fall in arterial resistance and a 20 per cent rise in stroke volume index compared with control. These findings show that hydralazine administration not only results in a beneficial effect on cardiac function at rest but that this effect is maintained during upright exercise in patients with impaired left ventricular function, thus providing further support for its use in the long-term management of such patients.
血管扩张剂药物的给药已被证明对急性或慢性心力衰竭患者的静息状态有有益作用。为了确定肼屈嗪在运动期间的疗效，对10名因弥漫性冠状动脉疾病或心肌病导致慢性左心室衰竭且症状严重的患者在静息状态和在自行车测力计上进行直立运动时进行了研究。所有患者均已接受洋地黄和利尿剂的最佳治疗。静息状态下使用肼屈嗪治疗导致平均动脉压和肺楔压均下降。与治疗前测量值相比，全身血管阻力降低了50%，每搏量指数同样显著增加。在运动期间，静息时观察到的变化持续存在，尽管程度较小；因此，与对照组相比，动脉阻力下降了20%，每搏量指数上升了20%。这些发现表明，使用肼屈嗪不仅对静息状态下的心脏功能有有益作用，而且在左心室功能受损的患者进行直立运动期间这种作用得以维持，从而为其在这类患者的长期管理中的应用提供了进一步支持。
