地西泮血浆和唾液水平的比较。
Comparison of plasma and saliva levels of diazepam.
作者信息
de Gier J J, t Hart B J, Wilderink P F, Nelemans F A
出版信息
Br J Clin Pharmacol. 1980 Aug;10(2):151-5. doi: 10.1111/j.1365-2125.1980.tb01732.x.
Abstract
- Salivary, unbound and total plasma levels of diazepam have been compared in nineteen subjects. 2. Salivary diazepam levels were significantly higher (P < 0.001) than, but closely related to the corresponding unbound levels (r = 0.97) at 2.5-3 h after administration of the drug. 3. The results presented suggest that saliva levels can be used to predict the corresponding plasma levels at a given time, but there is no 1:1 relation between the unbound diazepam concentration in plasma and the saliva level of the drug.
摘要
- 对19名受试者的唾液、游离和总血浆地西泮水平进行了比较。2. 给药后2.5 - 3小时，唾液地西泮水平显著高于相应的游离水平（P < 0.001），但二者密切相关（r = 0.97）。3. 给出的结果表明，唾液水平可用于预测给定时间的相应血浆水平，但血浆中游离地西泮浓度与药物的唾液水平之间不存在1:1的关系。
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