Ylikorkala O, Rönnberg L
Br J Obstet Gynaecol. 1980 Oct;87(10):911-5. doi: 10.1111/j.1471-0528.1980.tb04448.x.
To study the prolactin secretion and its dependence on the sex steroid concentrations during pregnancy, we measured the circulating prolactin, oestradiol-17 beta, progesterone and testosterone levels following vacuum curettage for termination of early pregnancy in 10 normal women and in 10 other women whose prolactin levels had been lowered with bromocriptine treatment. In normal women, anaesthesia and vacuum curettage led to consistent and significant (p < 0.01) rises in prolactin levels between 0.5 to 5 hours after abortion. This increase was not seen in women treated with bromocriptine whose prolactin level of 8.6 +/- 1.4 ng/ml (mean +/- SE) before abortion was lower than that of 29.6 +/- 6.4 ng/ml found in normal women. The oestradiol and progesterone concentrations decreased rapidly but similarly in both groups of patients following the evacuation of the uterus, whereas the testosterone level did not change significantly. These results indicate: (i) vacuum curettage stimulates prolactin secretion, (ii) the prolactin-stimulating effect of stress appears to be stronger than the prolactin-suppressing effect of postabortal oestradiol and/or progesterone declines, and (iii) bromocriptine blocks the stress-induced prolactin rise.
为研究孕期催乳素分泌及其对性类固醇浓度的依赖性，我们测量了10名正常女性以及另外10名经溴隐亭治疗使催乳素水平降低的女性在早期妊娠终止行真空刮宫术后的循环催乳素、雌二醇-17β、孕酮和睾酮水平。在正常女性中，麻醉和真空刮宫导致流产后0.5至5小时催乳素水平持续且显著升高（p < 0.01）。在经溴隐亭治疗的女性中未观察到这种升高，她们流产前催乳素水平为8.6 +/- 1.4 ng/ml（均值 +/- 标准误），低于正常女性的29.6 +/- 6.4 ng/ml。两组患者在子宫排空后雌二醇和孕酮浓度均迅速下降，但下降情况相似，而睾酮水平无显著变化。这些结果表明：（i）真空刮宫刺激催乳素分泌；（ii）应激对催乳素的刺激作用似乎强于流产后雌二醇和/或孕酮下降对催乳素的抑制作用；（iii）溴隐亭可阻断应激诱导的催乳素升高。
