Bogdanova I M, Malaĭtsev V V
Biull Eksp Biol Med. 1980 Oct;90(10):453-6.
The effect of different antisera to cell surface antigens on EA-rosette formation was investigated. Anti-immunoglobulin serum causes almost total blockade of EA-rosette formation by murine spleen and bone marrow cells. Rabbit anti-mouse brain-associated theta-antigen immunoglobulin has the same effect on EA-rosette formation by murine splenocytes but it has a slight action on EA-rosette formation by rat splenocytes. The mixing of rat splenocytes and autologous or mouse thymocytes increased the blocking influence of anti-BA theta-immunoglobulin. These findings indicate a requirement for specific antigen in the test-system for blockade of EA-rosette formation. This antigen is not necessarily expressed on the surface of Fc-receptor-bearing cells.
研究了不同的细胞表面抗原抗血清对EA玫瑰花结形成的影响。抗免疫球蛋白血清几乎完全阻断了小鼠脾脏和骨髓细胞的EA玫瑰花结形成。兔抗小鼠脑相关θ抗原免疫球蛋白对小鼠脾细胞的EA玫瑰花结形成有相同作用，但对大鼠脾细胞的EA玫瑰花结形成作用轻微。大鼠脾细胞与自体或小鼠胸腺细胞混合增加了抗BA θ免疫球蛋白的阻断作用。这些发现表明，在测试系统中阻断EA玫瑰花结形成需要特定抗原。该抗原不一定在携带Fc受体的细胞表面表达。
