Russell J A
Cell Tissue Res. 1980;212(2):315-31. doi: 10.1007/BF00233964.
The separation of function between and within the paraventricular (PV) and supraoptic (SO) nuclei was investigated in the rat. Nucleolar dry mass of PV and SO neurones was measured to detect increased synthetic activity after water deprivation for 3 days, lactation for 8 days or water deprivation during days 5 to 8 of lactation. Lactation or water deprivation increased nucleolar dry mass in both PV and SO neurones. These stimuli caused similar nucleolar changes in PV neurones, but water deprivation caused greater changes in SO neurones than lactation. The effects of lactation and water deprivation were additive for both SO and PV neurones. Furosemide was used to intensify the dehydration stimulus to determine whether such intensification could have caused the greater nucleolar changes when lactation and water deprivation were combined. For PV neurones this was not the case, but remained a possibility for SO neurones. Measurements of serum osmolality in the experimental groups were ranked as follows: water deprivation + furosemide > lactation + water deprivation > water deprivation > lactation = virgin control. Loss of body weight was similar in the first two groups but less during water deprivation alone. Although milk yield fell, milk was obtained by the litters of lactating animals throughout the period of water deprivation.
研究了大鼠室旁核（PV）和视上核（SO）内及之间的功能分离情况。测量PV和SO神经元的核仁干质量，以检测在3天禁水、8天哺乳或哺乳期第5至8天禁水后合成活性的增加。哺乳或禁水均增加了PV和SO神经元的核仁干质量。这些刺激在PV神经元中引起相似的核仁变化，但禁水在SO神经元中引起的变化比哺乳更大。哺乳和禁水对SO和PV神经元的影响是相加的。使用呋塞米增强脱水刺激，以确定当哺乳和禁水同时存在时，这种增强是否会导致更大的核仁变化。对于PV神经元，情况并非如此，但对于SO神经元仍有可能。对实验组血清渗透压的测量结果排序如下：禁水+呋塞米>哺乳+禁水>禁水>哺乳=未生育对照。前两组体重减轻相似，但仅禁水时体重减轻较少。尽管产奶量下降，但在整个禁水期间，哺乳动物的幼崽仍能获得乳汁。
