人类和实验性高血压中的血浆儿茶酚胺

Plasma catecholamines in human and experimental hypertension.

作者信息

Kopin I J, McCarty R, Yamaguchi I

出版信息

Clin Exp Hypertens (1978). 1980;2(3-4):379-94. doi: 10.3109/10641968009037120.

DOI:10.3109/10641968009037120

Abstract

Plasma levels of norepinephrine reflect the rate of its release from sympathetic nerves. In patients with hypertension and in spontaneously hypertensive (SHR) rats basal plasma NE levels are normal. SHR rats are abnormally reactive to stress, as are the normotensive (WKY) strain from which they were derived. The amounts of NE released by sympathetic stimulation are similar in pithed SHR and WKY rats, but SHR rats have greater blood pressure responses. This may be due to diminished beta-adrenoceptor-mediated vasodilation in young SHR rats and structural changes in arterioles of older SHR rats. It is concluded that in SHR rats separate abnormalities of centrally-mediated responses to stress and of peripheral sensitivity to catecholamines contribute to the development and maintenance of elevated blood pressure.

摘要

去甲肾上腺素的血浆水平反映了其从交感神经释放的速率。在高血压患者和自发性高血压（SHR）大鼠中，基础血浆去甲肾上腺素水平正常。SHR大鼠对应激异常敏感，其来源的正常血压（WKY）品系大鼠也是如此。在脊髓横断的SHR大鼠和WKY大鼠中，交感神经刺激释放的去甲肾上腺素量相似，但SHR大鼠的血压反应更大。这可能是由于年轻SHR大鼠中β-肾上腺素能受体介导的血管舒张减弱以及老年SHR大鼠小动脉的结构变化。得出的结论是，在SHR大鼠中，中枢介导的应激反应异常和外周对儿茶酚胺的敏感性异常共同促成了血压升高的发生和维持。