McLaughlin M K, Chez R A
Clin Exp Hypertens (1978). 1980;2(5):851-63. doi: 10.3109/10641968009037146.
The effects of Sar1Ala8 AII (Saralasin), an angiotensin II (AII) receptor blocker, were examined in the late gestation ewe and fetus. Maternal administration of Saralasin resulted in a reduction in both mean maternal systemic arterial pressure and uterine blood flow. There were no changes in the measured fetal indices during maternal drug administration. Infusion of Saralasin to the fetus caused variable reductions in mean fetal arterial blood pressure and umbilical flow. There were no changes in maternal parameters measured. Therefore, in pregnant sheep in the third trimester, a component of normal uterine blood flow is maintained by endogenous AII, primarily through maintenance of adequate perfusion pressure.
研究了血管紧张素II（AII）受体阻滞剂Sar1Ala8 AII（沙拉新）对妊娠晚期母羊和胎儿的影响。给母羊注射沙拉新会导致母羊平均体循环动脉压和子宫血流量均降低。在给母羊用药期间，所测量的胎儿指标没有变化。给胎儿输注沙拉新会使胎儿平均动脉血压和脐血流量出现不同程度的降低。所测量的母体参数没有变化。因此，在妊娠晚期的怀孕绵羊中，正常子宫血流量的一部分由内源性AII维持，主要是通过维持足够的灌注压来实现。
