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Iodothyronine 5'-deiodinase from rat kidney: substrate specificity and the 5'-deiodination of reverse triiodothyronine.

作者信息

Leonard J L, Rosenberg I N

出版信息

Endocrinology. 1980 Nov;107(5):1376-83. doi: 10.1210/endo-107-5-1376.

DOI:10.1210/endo-107-5-1376
PMID:7428675
Abstract
摘要

相似文献

1
Iodothyronine 5'-deiodinase from rat kidney: substrate specificity and the 5'-deiodination of reverse triiodothyronine.大鼠肾脏中的碘甲状腺原氨酸5'-脱碘酶：底物特异性及反式三碘甲状腺原氨酸的5'-脱碘作用
Endocrinology. 1980 Nov;107(5):1376-83. doi: 10.1210/endo-107-5-1376.
2
Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex.动力学证据表明大鼠大脑皮层中碘甲状腺原氨酸5'-脱碘存在两种机制。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):5080-4. doi: 10.1073/pnas.79.16.5080.
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Iodothyronine 5'-deiodination in rat kidney microsomes: sensitivity to propylthiouracil.大鼠肾微粒体中的碘甲状腺原氨酸5'-脱碘作用：对丙硫氧嘧啶的敏感性。
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4
Iodothyronine 5'-deiodinase in rat kidney microsomes. Kinetic behavior at low substrate concentrations.大鼠肾微粒体中的碘甲状腺原氨酸5'-脱碘酶。低底物浓度下的动力学行为。
J Clin Invest. 1984 Dec;74(6):2097-106. doi: 10.1172/JCI111634.
5
Iodothyronine deiodinase activities in FRTL5 cells: predominance of type I 5'-deiodinase.FRTL5细胞中的碘甲状腺原氨酸脱碘酶活性：I型5'-脱碘酶占主导。
Endocrinology. 1990 Jun;126(6):3059-68. doi: 10.1210/endo-126-6-3059.
6
Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism.大鼠垂体中存在两种碘甲状腺原氨酸5'-脱碘途径的证据，这两种途径在动力学、丙硫氧嘧啶敏感性及对甲状腺功能减退的反应方面存在差异。
J Clin Invest. 1983 Apr;71(4):992-1002. doi: 10.1172/jci110854.
7
A study of the properties of the enzyme in rat liver that deiodinates 3,3'5'-triiodothyronine to 3,3'-diiodothyronine.
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Comparison of kidney and brown adipose tissue iodothyronine 5'-deiodinases.肾脏与棕色脂肪组织甲状腺原氨酸5'-脱碘酶的比较
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Inhibition by coumadin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines.
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Rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase.大鼠肝脏脱碘酶对硫酸甲状腺素的快速选择性内环脱碘作用。
Endocrinology. 1985 Jul;117(1):8-12. doi: 10.1210/endo-117-1-8.

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Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice.
甲状腺激素状态定义了小鼠棕色脂肪组织的活性和白色脂肪组织的褐变。
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Eur Thyroid J. 2015 Sep;4(Suppl 1):87-91. doi: 10.1159/000381021. Epub 2015 May 23.
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Endocrine. 1995 Aug;3(8):597-601. doi: 10.1007/BF02953025.
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Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells.2 型碘甲状腺原氨酸脱碘酶活性中心丝氨酸取代脯氨酸会显著改变其在体外生化特性，但不改变其在完整细胞中的功能。
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Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups.围产期多溴二苯醚暴露对雄性幼鼠肝脏中参与甲状腺激素代谢的Ⅰ相、Ⅱ相、Ⅲ相代谢酶及脱碘酶1基因表达的影响。
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