Baer D S, McClearn G E, Wilson J R
Dev Psychobiol. 1980 Nov;13(6):643-52. doi: 10.1002/dev.420130611.
Female mice from lines selectively bred for differences in open-field activity were exposed to tobacco smoke during gestation. Smoke-treated females were less likely than controls to have produced litters by 23 days after observation of a vaginal plug. Within the high-active line, fewer pups of smoke-treated dams survived to weaning. Regardless of treatment, fewer high-active than low-active offspring survived to weaning. Results of a 4-day series of open-field activity tests administered to offspring beginning at 28 days of age indicated that tobacco smoke administered prenatally and/or during testing depresses open-field activity in both lines. Other activity tests administered at 50 days of age gave similar results. Tissue nicotine levels after nicotine injection tended to be higher in high-active and control groups than in low-active and smoke-treated groups, respectively. Liver weight expressed as percentage of body weight was 11.9% greater in smoke-treated animals than in controls.
对因旷场活动差异而经选择性培育的品系的雌性小鼠，在其孕期使其暴露于烟草烟雾中。与对照组相比，经烟雾处理的雌性小鼠在观察到阴栓后23天内产仔的可能性较小。在高活动品系中，经烟雾处理的母鼠所产幼崽存活至断奶的数量较少。无论处理方式如何，存活至断奶的高活动后代比低活动后代少。对28日龄开始的后代进行的为期4天的旷场活动系列测试结果表明，产前和/或测试期间给予烟草烟雾会抑制两个品系的旷场活动。在50日龄时进行的其他活动测试也得到了类似结果。尼古丁注射后，高活动组和对照组的组织尼古丁水平分别往往高于低活动组和经烟雾处理组。经烟雾处理的动物肝脏重量占体重的百分比比对照组高11.9%。
