西咪替丁治疗患者出现的激动、定向障碍和幻觉：三例报告及文献综述

Agitation, disorientation, and hallucinations in patients on cimetidine: a report of three cases and literature review.

作者信息

Yudofsky S C, Ahern G, Brockman R

出版信息

Gen Hosp Psychiatry. 1980 Sep;2(3):233-6. doi: 10.1016/0163-8343(80)90068-7.

Abstract

Cimetidine, the first of a new class of pharmacologic agents that dramatically inhibit basal gastric acid secretion, is achieving widespread use for the treatment of such acid peptic disorders as duodenal ulcers, gastritis, and reflux esophagitis. Three patients are presented who experienced agitation, disorientation, and hallucinations while being treated with cimetidine. A review of the literature revealed that central nervous system side effects of cimetidine can occur within 24 hours of treatment with the drug; are often unrecognized or misdiagnosed by clinicians, and are reversed within 12 to 48 hours after the discontinuation of the medication.

摘要

西咪替丁是一类能显著抑制基础胃酸分泌的新型药理药物中的首个药物，正广泛用于治疗十二指肠溃疡、胃炎和反流性食管炎等酸相关性疾病。本文报告了3例在接受西咪替丁治疗时出现激动、定向障碍和幻觉的患者。文献回顾显示，西咪替丁的中枢神经系统副作用可在用药后24小时内出现；临床医生常常未识别或误诊这些副作用，且在停药后12至48小时内这些副作用会消失。