大鼠急性一氧化碳中毒期间的肝损伤
Liver damage in rats during acute carbon monoxide poisoning.
作者信息
Katsumata Y, Aoki M, Oya M, Yada S, Suzuki O
出版信息
Forensic Sci Int. 1980 Sep-Oct;16(2):119-23. doi: 10.1016/0379-0738(80)90164-4.
PMID:7429377
Abstract
Plasma leucine aminopeptidase (LAP) levels and respiration rates of isolated liver mitochondria were studied in carbon monoxide (CO)-poisoned rats sampled at respiratory arrest. An increase in LAP levels paralleled a decrease in the respiratory control ratio and the ADP/O ratio. The results suggest that the damage to mitochondria closely correlates with the liver damage in rats during acute CO poisoning.
摘要
在呼吸停止时采集的一氧化碳（CO）中毒大鼠中，研究了血浆亮氨酸氨基肽酶（LAP）水平和分离的肝线粒体的呼吸速率。LAP水平的升高与呼吸控制率和ADP/O比值的降低平行。结果表明，急性CO中毒期间大鼠线粒体的损伤与肝脏损伤密切相关。
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