Turi G K, Albala A, Fenoglio J J
Hum Pathol. 1980 Sep;11(5 Suppl):577-80.
The fine structure of a surgically resected cardiac fibroma is described. The tumor consisted primarily of fibroblasts set in a matrix composed of acid mucopolysaccharide and collagen. Many of the fibroblasts contained abundant myofilaments and dense bodies, suggesting differentiation or transformation of these cells to myofibroblasts. No striated muscle was identified. This study confirms the fact that the cardiac fibroma is derived from connective tissue elements and should not be considered either a hamartoma or a mesoblastic tumor. Structurally, as well as biologically, the cardiac fibroma closely resembles soft tissue fibromatoses and should be considered an example of cardiac fibromatosis.
本文描述了手术切除的心脏纤维瘤的精细结构。肿瘤主要由成纤维细胞组成，这些细胞位于由酸性粘多糖和胶原蛋白构成的基质中。许多成纤维细胞含有丰富的肌丝和致密体，提示这些细胞分化或转化为肌成纤维细胞。未发现横纹肌。本研究证实了心脏纤维瘤起源于结缔组织成分这一事实，不应将其视为错构瘤或中胚层肿瘤。在结构和生物学方面，心脏纤维瘤与软组织纤维瘤病极为相似，应被视为心脏纤维瘤病的一个实例。
