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兔外周血和腹腔中性粒细胞的表面膜酶、趋化肽结合活性及趋化反应性

Surface membrane enzyme, chemotactic peptide binding activities, and chemotactic responsiveness of rabbit peripheral and peritoneal neutrophils.

作者信息

Tsung P K, Showell H J, Becker E L

出版信息

Inflammation. 1980 Sep;4(3):271-7. doi: 10.1007/BF00915028.

DOI:10.1007/BF00915028
PMID:7429607
Abstract

The chymotrypsin-like esterase activity of plasma membrane and the ecto-5'nucleotidase and ecto-p-nitrophenyl phosphatase activities in peritoneal neutrophils are 2- and 3-fold higher than peripheral blood neutrophils. The binding of the chemotactic peptide, formyl norleucyl-leucyl-phenyl-alanine to peritoneal neutrophils is 6- to 7-fold higher than to peripheral blood neutrophils. The chemotactic responsiveness of peritoneal neutrophils to the chemotactic peptide is 5-fold greater than peripheral blood neutrophils. However, there was no significant difference in the chemotactic responsiveness to complement component C5a between the blood and peritoneal cells.

摘要

腹膜中性粒细胞的质膜类胰凝乳蛋白酶样酯酶活性、胞外5'-核苷酸酶活性和胞外对硝基苯磷酸酶活性比外周血中性粒细胞高2至3倍。趋化肽甲酰基去甲亮氨酰-亮氨酰-苯丙氨酸与腹膜中性粒细胞的结合比与外周血中性粒细胞的结合高6至7倍。腹膜中性粒细胞对趋化肽的趋化反应性比外周血中性粒细胞高5倍。然而，血液和腹膜细胞对补体成分C5a的趋化反应性没有显著差异。

相似文献

1
Surface membrane enzyme, chemotactic peptide binding activities, and chemotactic responsiveness of rabbit peripheral and peritoneal neutrophils.兔外周血和腹腔中性粒细胞的表面膜酶、趋化肽结合活性及趋化反应性
Inflammation. 1980 Sep;4(3):271-7. doi: 10.1007/BF00915028.
2
The evidence for the existence of chymotrypsin-like esterase activity in the plasma membranes of rabbit neutrophils and the specific chemotactic peptide binding activity of the subcellular fractions.兔中性粒细胞质膜中类胰凝乳蛋白酶酯酶活性存在的证据以及亚细胞组分的特异性趋化肽结合活性。
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Endotoxin-induced selective dysfunction of rabbit polymorphonuclear leukocytes in response to endogenous chemotactic factors.内毒素诱导兔多形核白细胞对内源性趋化因子反应的选择性功能障碍。
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4
The formylpeptide chemotactic receptor on rabbit peritoneal neutrophils. I. Evidence for two binding sites with different affinities.兔腹膜嗜中性粒细胞上的甲酰肽趋化受体。I. 具有不同亲和力的两个结合位点的证据。
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Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.兔中性粒细胞质膜结合GTP酶的特性研究。I. 与甲酰肽、C5a和白三烯B4趋化性受体偶联的类镍蛋白的证据。
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引用本文的文献

1
Inhibition of neutrophil chemotaxis by protease inhibitors. Differential effect of inhibitors of serine and thiol proteases.蛋白酶抑制剂对中性粒细胞趋化性的抑制作用。丝氨酸蛋白酶抑制剂和硫醇蛋白酶抑制剂的不同作用效果。
Inflammation. 1995 Oct;19(5):561-74. doi: 10.1007/BF01539136.
2
Modulation of PMN receptors for chemotactic peptides.趋化肽的中性粒细胞受体调节
Surv Immunol Res. 1983;2(2):139-44. doi: 10.1007/BF02918572.
3
Endotoxin pretreatment enhances neutrophil FMLP-receptor binding and activity in guinea pigs.内毒素预处理可增强豚鼠中性粒细胞的甲酰甲硫氨酸-亮氨酸-苯丙氨酸（FMLP）受体结合能力及活性。

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Biochemical demonstration of the activatable esterase of the rabbit netrophil involved in the chemotactic response.参与趋化反应的兔嗜中性粒细胞可激活酯酶的生化证明。
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Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque.红细胞、粒细胞和单核白细胞在菲可-泛影葡胺不连续密度梯度上的一步分离。
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Inhibitor of adenosine 3',5'-monophosphate binding and protein kinase activity in leucocyte lysosomes.白细胞溶酶体中腺苷3',5'-单磷酸结合及蛋白激酶活性抑制剂。
Biochem Biophys Res Commun. 1973 Apr 16;51(4):836-42. doi: 10.1016/0006-291x(73)90002-8.
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Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells.从分离的大鼠脂肪细胞制备质膜和内质网片段及其性质
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The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.合成肽作为中性粒细胞趋化因子和溶酶体分泌诱导剂的构效关系。
J Exp Med. 1976 May 1;143(5):1154-69. doi: 10.1084/jem.143.5.1154.
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Chemotactic activity from rabbit peritoneal neutrophils. Lack of identity with N-acetyl-DL-phenylalanine beta-napthyl esterase.来自兔腹膜中性粒细胞的趋化活性。与N-乙酰-DL-苯丙氨酸β-萘酯酶不同。
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Synthesis and binding characteristics of an intrinsically radiolabeled chemotactic acyl tripeptide. N alpha-Formyl--norleucyl--leucyl--phenylalanine.一种内源性放射性标记趋化酰基三肽的合成及结合特性。Nα-甲酰基-去甲亮氨酰-亮氨酰-苯丙氨酸。
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