Lai M, Lewis P D
J Comp Neurol. 1980 Oct 15;193(4):973-82. doi: 10.1002/cne.901930410.
Rats were undernourished by halving the mother's food intake from the sixth day of pregnancy onwards and through lactation. Subsequently, the young animals were maintained up to 48 days on half the normal diet. The effects of this regime of treatment on myelination in the corpus callosum were investigated by light and electron microscopy. In comparison with controls, the percentage of axons myelinated at 15, 21, and 48 days was reduced in undernourished rats. The number of lamellae constituting the myelin sheath was also reduced at 15 and 21 days, but at 48 days no difference was seen between control and treated rats, suggesting that a catch-up in myelination had occurred. A linear relationship between myelin sheath thickness and axonal diameter was observed in both groups of animals. However, a long-term effect on axonal growth was suggested by findings in the 48-day undernourished animals; in comparison with controls, axonal diameter was reduced, relative to myelin sheath thickness.
从怀孕第六天起直至哺乳期，将母鼠的食物摄入量减半，以此使幼鼠营养不良。随后，幼鼠在正常饮食量减半的情况下饲养至48天。通过光学显微镜和电子显微镜研究了这种处理方式对胼胝体髓鞘形成的影响。与对照组相比，营养不良大鼠在15天、21天和48天时髓鞘化轴突的百分比降低。构成髓鞘的板层数量在15天和21天时也减少，但在48天时，对照组和处理组大鼠之间未见差异，这表明髓鞘形成已出现追赶现象。两组动物均观察到髓鞘厚度与轴突直径之间呈线性关系。然而，48天龄营养不良动物的研究结果提示对轴突生长有长期影响；与对照组相比，相对于髓鞘厚度，轴突直径减小。
