Mason S T, Lin D
J Comp Physiol Psychol. 1980 Oct;94(5):819-32. doi: 10.1037/h0077826.
The role for the dorsal noradrenergic bundle (DNB) in selective attention and stimulus filtering was tested in several situations. The DNB was damaged by stereotaxically guided injections of 4 microgram of the neurotoxin 6-hydroxydopamine (6-OHDA). The latent inhibition effect was blocked by 6-OHDA-induced depletion of forebrain noradrenaline, whereas nonreversal shift performance was better in noradrenaline-depleted rats than controls. These data are interpreted to indicate that animals with DNB lesions are imparied in ignoring irrelevant stimuli. However, in situations in which control animals did not learn to ignore irrelevant stimuli, no lesion-induced difference was found. Thus, controls and animals with DNB lesions learned equally about each of two dimensions of a multiple-redundant discrimination task. This was assessed both by interpolated trials with only one dimension present and by shifts in which only one of the previous two dimensions remained relevant. It is concluded that the DNB lesion does not increase stimulus sampling globally but that it impairs performance only in those cases in which normal rats learn to ignore irrelevant stimuli.
在多种情况下对背侧去甲肾上腺素能束（DNB）在选择性注意和刺激筛选中的作用进行了测试。通过立体定位引导注射4微克神经毒素6-羟基多巴胺（6-OHDA）来损伤DNB。6-OHDA诱导的前脑去甲肾上腺素耗竭会阻断潜在抑制效应，而在去甲肾上腺素耗竭的大鼠中，非逆转转换任务的表现优于对照组。这些数据被解释为表明具有DNB损伤的动物在忽略无关刺激方面存在缺陷。然而，在对照动物没有学会忽略无关刺激的情况下，未发现损伤诱导的差异。因此，对照组和具有DNB损伤的动物在多重冗余辨别任务的两个维度上的学习效果相同。这通过仅呈现一个维度的内插试验以及仅使前两个维度中的一个保持相关的转换来评估。得出的结论是，DNB损伤不会全局增加刺激采样，但仅在正常大鼠学会忽略无关刺激的情况下会损害表现。
