成人对破伤风类毒素的体内和体外细胞介导免疫

In vivo and in vitro cell-mediated immunity to tetanus toxoid in adults.

作者信息

Fairshter R D, Thornton D B, Gottschalk H R, Slater L M, Galant S P

出版信息

J Allergy Clin Immunol. 1980 Dec;66(6):452-7. doi: 10.1016/0091-6749(80)90005-6.

Abstract

The purpose of this study was to evaluate tetanus toxoid (TT) as an indicator of cutaneous delayed hypersensitivity (CDH) in adults. Fifty-two normal subjects, aged 25 to 64 yr, were skin tested with TT and streptokinase-streptodornase (SK/SD). Lymphocyte transformation was studied in seven normal TT reactors, four normal TT nonreactors, and seven hospitalized anergic patients. CDH was common with both TT and SK/SD; 90% of the adults, aged 25 to 39 yr, had CDH reactions to TT and 79% had CDH reactions to SK/SD. In adults aged 40 to 64 yr, 75% had DCH reactions to TT and 59% had CDH reactions to SK/SD. Lymphocyte transformation to TT correlated well with TT skin-test results. Punch biopsy specimens of TT reactions 48 hr after skin testing demonstrated DCH. We conclude that TT is an excellent antigen for assessing the presence or absence of CDH in adults aged 25 to 64 yr.

摘要

本研究的目的是评估破伤风类毒素（TT）作为成人皮肤迟发型超敏反应（CDH）指标的价值。52名年龄在25至64岁的正常受试者接受了TT和链激酶 - 链道酶（SK/SD）皮肤试验。对7名TT反应阳性的正常受试者、4名TT反应阴性的正常受试者和7名住院的无反应性患者进行了淋巴细胞转化研究。TT和SK/SD引起的CDH都很常见；25至39岁的成年人中，90%对TT有CDH反应，79%对SK/SD有CDH反应。在40至64岁的成年人中，75%对TT有迟发型超敏反应（DCH），59%对SK/SD有CDH反应。淋巴细胞对TT的转化与TT皮肤试验结果密切相关。皮肤试验48小时后TT反应部位的打孔活检标本显示为迟发型超敏反应。我们得出结论，TT是评估25至64岁成年人是否存在CDH的优良抗原。