Turut P, Malthieu D
J Fr Ophtalmol. 1980;3(6-7):401-8.
Cephaloridine is an antibiotic well known for its remarkable efficacy and absence of ocular toxicity. However four cases have been reported with severe ocular affect; a unilateral retinitis pigmentosa with extinction of the E.R.G. and total irreversible blindness has been noted in three cases after sub-conjunctival or intra-camerular injection of cephaloridine, one case showed a slight improvement. In an experimental study undertaken on rabbits no ocular toxicity has been noted during sub-conjunctival or intra-camerular injection whilst very low doses of intravitreous injection reproduce exactly the same facts as observed in man. These various studies give proof of the ocular toxicity of cephaloridine and involves particular caution in its utilizaiton for endo-ocular diseases.
头孢噻啶是一种以其显著疗效和无眼毒性而闻名的抗生素。然而，已有4例严重眼部不良反应的报道；3例在结膜下或前房内注射头孢噻啶后出现单侧视网膜色素变性，伴有视网膜电图熄灭和完全不可逆失明，1例稍有改善。在对兔子进行的一项实验研究中，结膜下或前房内注射时未发现眼毒性，而极低剂量的玻璃体内注射却产生了与人类观察到的完全相同的情况。这些不同的研究证明了头孢噻啶的眼毒性，因此在将其用于眼内疾病时需格外谨慎。
