Saunders J, Hall S E, Sönksen P H
Department of Medicine, St. Thomas's Hospital Medical School, London, England.
J Endocrinol Invest. 1980 Jul-Sep;3(3):309-11. doi: 10.1007/BF03348282.
Glucocorticoids are known to have acute effects on glucose and free fatty acid (FFA) metabolism. The effects of the longstanding hypercorticism of Cushing's syndrome were studied by isotopic techniques in a group of Cushingoid patients compared to a control group. In the Cushing's group, glucose production and utilization rates were significantly higher than in control subjects, while FFA turnover also tended to be higher, but not significantly. It is suggested that increased glucose production is the main cause of the hyperglycemia seen in Cushing's syndrome.
已知糖皮质激素对葡萄糖和游离脂肪酸（FFA）代谢有急性影响。通过同位素技术，在一组库欣综合征患者中研究了库欣综合征长期皮质醇增多的影响，并与对照组进行比较。在库欣综合征组中，葡萄糖生成和利用率显著高于对照组，而游离脂肪酸周转率也有升高趋势，但无显著差异。提示葡萄糖生成增加是库欣综合征中高血糖的主要原因。
