Gauss-Müller V, Kleinman H K, Martin G R, Schiffmann E
J Lab Clin Med. 1980 Dec;96(6):1071-80.
Fibroblasts require both a collagen substratum and fibronectin for adherence and subsequent migration in the Boyden chamber. Both fibronectin and lymphokines are good chemoattractants, whereas the collagens are weaker. Fibroblasts appear to require cytoskeletal organization and methylation reactions for chemotaxis, properties shown previously for macrophages and neutrophils. Fibroblasts, however, migrate more slowly than phagocytic cells and appear to require protein synthesis.
成纤维细胞在博伊登小室中黏附及后续迁移既需要胶原蛋白基质，也需要纤连蛋白。纤连蛋白和淋巴因子都是良好的化学引诱剂，而胶原蛋白的作用则较弱。成纤维细胞趋化似乎需要细胞骨架组织和甲基化反应，巨噬细胞和中性粒细胞先前也显示出这些特性。然而，成纤维细胞的迁移速度比吞噬细胞慢，且似乎需要蛋白质合成。
