5-氟尿嘧啶处理的仓鼠胎儿腭裂发育的形态学研究。
Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses.
作者信息
Shah R M, Wong D T
出版信息
J Embryol Exp Morphol. 1980 Jun;57:119-28.
Morphogenesis of palate was studied in normal and 5-fluorouracil-treated hamster fetuses. The results showed that normal palatal development was completed between days 12 and 13 of gestation. In 5-fluorouracil-assaulted palate the reorientation of shelves from a vertical to horizontal plane was delayed. Crown-rump length, gestational age and fetal weight were reliable predictors of the stages of normal palatal development, whereas the morphological rating system was not. Following 5-fluorouracil treatment, however, crown-rump length, weight and morphological rating were poor indicators of the stage of palatal development.
在正常和经5-氟尿嘧啶处理的仓鼠胎儿中研究了腭的形态发生。结果表明，正常的腭发育在妊娠第12天至第13天之间完成。在受5-氟尿嘧啶影响的腭中，腭板从垂直平面重新定向到水平平面的过程被延迟。顶臀长度、胎龄和胎儿体重是正常腭发育阶段的可靠预测指标，而形态评分系统则不是。然而，在5-氟尿嘧啶处理后，顶臀长度、体重和形态评分是腭发育阶段的不良指标。
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