关于十二指肠溃疡病因的心理生理学假说。

A psychophysiological hypothesis on the aetiology of duodenal ulceration.

作者信息

Levin A, Katzeff I E, Schlebusch L, Moshal M G, Schlemmer L, Goolam-Hoosen I, Naidoo N K

出版信息

Med Hypotheses. 1980 Sep;6(9):987-95. doi: 10.1016/0306-9877(80)90050-x.

Abstract

A previously undescribed explanation for the development of duodenal ulcer is advanced. Stressful situations and avoidance-avoidance conflicts in individuals with a dependant compliant personality incapable of appropriate "stimulus-seeking behaviour" lead to an immobilised state. This predicament is denied. Helplessness develops. This state is associated with an autonomic imbalance in which a central monoamine depletion results in uncompensated parasympathetic overactivity which facilitates the development of duodenal ulceration. Denial often invalidates superficial psychological investigations into the aetiology of duodenal ulceration and may explain the contradictory findings in the literature.

摘要

本文提出了一种关于十二指肠溃疡发病机制的全新解释。对于具有依赖顺从型人格、无法进行适当“刺激寻求行为”的个体而言，压力情境和回避-回避冲突会导致其进入一种静止状态。这种困境被否认，继而产生无助感。这种状态与自主神经失衡相关，其中中枢单胺耗竭导致未得到代偿的副交感神经活动过度，进而促进十二指肠溃疡的发展。否认常常使对十二指肠溃疡病因的表面心理调查无效，这可能解释了文献中相互矛盾的研究结果。