Hironaga M, Watanabe S
Sabouraudia. 1980 Sep;18(3):229-35. doi: 10.1080/00362178085380371.
A rare case is presented of mycotic infection in a Japanese female, who had cutaneous alternariosis in the face at age 9, and died of cerebral phacohyphomycosis 8 years later. To our knowledge, this is the first reported case in which these two unusual and different mycoses have occurred successively in the same person. The cerebral lesions were located in the right parietal region close to the sulcus centralis and in the region of the right cerebral lateral fissure. They were granulomatous and characterized by the presence of numerouse microabscesses. In the center of these were seen many dematiaceous fungal elements that consisted mainly of light brown, septate hyphae 1.5-2.5 micrometer in diameter, from which elongated cells 3-4 X 8-10 microgram in size were seen proliferating. In addition, yeast-like cells 8-10 microgram in diameter were observed. The etiologic agent isolated from the brain lesions was identified as Cladosporium bantianum (Sace.) Borelli (=Cladosporium trichnoides Emmons) on the basis of our morphological and physiological findings and its neurotropism in experimentally inoculated mice.
本文报告一例罕见的霉菌感染病例，患者为日本女性，9岁时面部患皮肤链格孢菌病，8年后死于脑暗色丝孢霉病。据我们所知，这是首例同一患者先后发生这两种罕见且不同霉菌感染的报告病例。脑部病变位于右侧顶叶靠近中央沟处及右侧大脑外侧裂区域。病变为肉芽肿性，其特征是存在大量微脓肿。在这些微脓肿中心可见许多暗色真菌成分，主要由直径1.5 - 2.5微米的浅棕色、有隔菌丝组成，从中可见大小为3 - 4×8 - 10微米的细长细胞增殖。此外，还观察到直径8 - 10微米的酵母样细胞。根据我们的形态学、生理学发现及其在实验接种小鼠中的嗜神经性，从脑部病变分离出的病原体被鉴定为班替枝孢霉（Sace.）Borelli（= 曲状枝孢霉Emmons）。
