Shlemkevich M P, Gnatyshak A I, Shiian D N
Vopr Onkol. 1980;26(10):36-40.
Two hundred radical operations on gastric tumor patients were performed in the Lvov oncological centre during 1974-1978. As a result of biochemical studies of gastric tumors some essential alterations were established in the 5FU-6-3H incorporation into the acid soluble fraction and in the activity of alkaline phosphatase in 5FU sensitive and resistant tumors. Additional chemotherapy with 5FU was carried out only for patients with tumors sensitive to the drug, due to it the 5-year survival rate in this group of patients has significantly raised.
1974年至1978年期间，利沃夫肿瘤中心对200例胃肿瘤患者进行了根治性手术。通过对胃肿瘤的生化研究，发现5-氟尿嘧啶（5FU）-6-³H掺入酸溶性部分以及5FU敏感和耐药肿瘤中碱性磷酸酶的活性存在一些重要变化。仅对药物敏感的肿瘤患者进行了5FU辅助化疗，因此该组患者的5年生存率显著提高。
