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[对K值效用的批判及葡萄糖同化系数的证据]

[Criticism of the K value-utility and evidence of the glucose assimilation coefficient].

作者信息

Möricke R, Caruso M, Andraczek F

出版信息

Z Gesamte Inn Med. 1980 Apr 15;35(8):325-30.

PMID:7434841
Abstract

Theoretical statements concerning the calculation of the K-value and explanations of the practical approach in the estimation of the K-value are the initial position. It is proved that it is not possible after a standardized glucose supply to establish by means of the K-value a true gradation of the glucose assimilation, which is independent on the population and lies on an absolute proportion scale, of any test persons on various conditions. Up to now this fact is not taken into consideration when the K-value is used and judged for the characterization of the glucose assimilation and leads to weighty errors in the kinetic evaluation of the measuring data. Since both the height of the fasting blood glucose and the speed of the glucose elimination are included as diagnostic separation criteria in the K-value, it is, on the other hand, well suited for the delimitation of latent, asymptomatic and manifest diabetics from persons with healthy metabolism.

摘要

关于K值计算的理论陈述以及K值估算中实际方法的解释是起始点。事实证明,在标准化葡萄糖供应后,不可能通过K值建立任何测试对象在各种条件下独立于人群且基于绝对比例尺度的葡萄糖同化的真实分级。到目前为止,在使用和判断K值以表征葡萄糖同化时,这一事实未被考虑在内,从而在测量数据的动力学评估中导致重大误差。另一方面,由于空腹血糖水平和葡萄糖消除速度都作为诊断区分标准包含在K值中,因此它非常适合于区分潜伏性、无症状性和显性糖尿病患者与代谢健康的人。

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