Burtin P, Pinset C, Chany E, Fondaneche M C, Chavanel G
Br J Cancer. 1978 Dec;38(6):685-91. doi: 10.1038/bjc.1978.273.
Leucocyte-migration-inhibition test was used to study the immune reactions of leucocytes from 136 colorectal cancer patients, 43 patients with non-cancerous chronic colorectal diseases and 82 controls, with saline extracts of HT29 line. A positive inhibition was found in only 43% of colorectal cancer patients. It was higher in carcinomas of limited extension than in invasive ones (64% against 39%). Furthermore, operation by itself had a depressive effect on the reaction, as the positivity in 25 patients tested twice was 64% before operation and 32% after. Leucocytes from patients with non-cancerous chronic colorectal diseases gave many positive reactions (65%). The percentage of positivity was about the same for diseases with high, low or no risk of cancerization. Hence the antigen(s) of tumour extracts that react with patient's leucocytes are, at least partially, unrelated to cancer.
采用白细胞游走抑制试验,以HT29细胞系的生理盐水提取物,研究了136例结直肠癌患者、43例非癌性慢性结直肠疾病患者和82例对照者白细胞的免疫反应。仅43%的结直肠癌患者出现阳性抑制。局限性癌的阳性率高于浸润性癌(分别为64%和39%)。此外,手术本身对反应有抑制作用,25例接受两次检测的患者术前阳性率为64%,术后为32%。非癌性慢性结直肠疾病患者的白细胞出现许多阳性反应(65%)。癌变风险高、低或无癌变风险的疾病,其阳性率大致相同。因此,肿瘤提取物中与患者白细胞发生反应的抗原,至少部分与癌症无关。