用从大肠肿瘤和正常结肠黏膜制备的提取物抑制大肠癌患者白细胞迁移。
Inhibition of leucocyte migration in patients with large intestinal cancer by extracts prepared from large intestinal tumours and from normal colonic mucosa.
作者信息
McIllmurray M B, Price M R, Langman M J
出版信息
Br J Cancer. 1974 Apr;29(4):305-11. doi: 10.1038/bjc.1974.71.
Abstract
The degree of migration inhibition in response to tissue extracts has been examined in leucocyte preparations obtained from patients with large intestinal cancer and from age and sex matched control individuals. A greater degree of migration inhibition was observed in response to a colorectal tumour extract in cells obtained from the cancer patients. Inhibition also tended to be more marked in response to the tumour extract than in response to a normal colonic mucosal extract in these patients. These results suggest that altered cellular immune reactivity is demonstrable by this simple in vitro technique in patients with large intestinal cancer.
摘要
在从大肠癌患者以及年龄和性别匹配的对照个体获得的白细胞制剂中，检测了对组织提取物的迁移抑制程度。在癌症患者的细胞中，对结肠直肠肿瘤提取物的反应观察到更大程度的迁移抑制。在这些患者中，对肿瘤提取物的抑制作用也往往比对正常结肠黏膜提取物的抑制作用更明显。这些结果表明，通过这种简单的体外技术，在大肠癌患者中可证明细胞免疫反应性发生了改变。
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