Katalymov L L
Biol Bull Acad Sci USSR. 1978 Mar-Apr;5(2):188-97.
It has been found that the duration of the absolute and relative refractory phases at individual nodes of Ranvier in myelinated nerve fibers is longer (by 39 and 33%, respectively) than in the nerve as a whole. In addition, at individual nodes of Ranvier in isolated nerve fibers the phases of facilitation and prolonged subnormality are absent. If, however, one prepares single nerve fibers taking precautions against stretching the node of Ranvier (preparations with "closed" and "sheltered" nodes), one may observe in them both facilitation and prolongation of the subnormal phase. It has been concluded that the procedure for preparing single nerve fibers leads to substantial changes in the functional properties of the excitable membrane at the node of Ranvier and disturbs the integrity of the surrounding ionic barrier.
已发现，有髓神经纤维中单个郎飞结处的绝对不应期和相对不应期的持续时间比整个神经中的更长（分别长39%和33%）。此外，在分离的神经纤维中的单个郎飞结处，不存在易化期和延长的低常期。然而，如果在制备单根神经纤维时采取预防措施防止郎飞结拉伸（制备有“封闭”和“保护”结的标本），则在其中可观察到易化期和低常期的延长。得出的结论是，制备单根神经纤维的操作会导致郎飞结处可兴奋膜的功能特性发生实质性变化，并破坏周围离子屏障的完整性。
