Ghabriel M N, Allt G
Acta Neuropathol. 1980;52(2):97-104. doi: 10.1007/BF00688006.
A mechanism has been proposed previously for the formation of Schmidt-Lanterman incisures during ontogeny as myelinated nerve fibres increase in diameter. In this study, the mode of formation of incisures and their development were examined by light and electron microscopy in remyelinating fibres (16-200 d) of the sural nerve of rats following lysophosphatidyl choline (LPC)-induced segmental demyelination. In remyelination, a basic number of incisures is incorporated into the myelin sheath ab initio. Apparently these incisures which are at first circumferentially incomplete, being localised to the region of the mesaxons, progressively extend around the whole circumference of the myelin sheath. As fibre diameter increases, additional incisures are added, seemingly, by the intrusion of Schwann cell cytoplasm between the compact myelin lamellae, from the abaxonal side of the myelin sheath. The progressive differentiation of incisures is described in terms of their complement of organelles. The results are discussed with reference to the possible functions of incisures.
先前已提出一种机制，用于解释在个体发育过程中，随着有髓神经纤维直径增加，施密特-兰特尔曼切迹的形成。在本研究中，通过光镜和电镜检查了大鼠腓肠神经在溶血磷脂酰胆碱（LPC）诱导的节段性脱髓鞘后再髓鞘化纤维（16 - 200天）中切迹的形成方式及其发育过程。在再髓鞘化过程中，一定数量的切迹从一开始就被纳入髓鞘。显然，这些最初在圆周上不完整、位于轴系膜区域的切迹，会逐渐围绕髓鞘的整个圆周延伸。随着纤维直径增加，似乎通过雪旺细胞胞质从髓鞘的无轴突侧侵入紧密髓鞘板层之间，增加了额外的切迹。根据切迹所含细胞器的情况描述了切迹的逐步分化。并参照切迹可能的功能对结果进行了讨论。
