一些具有肌肉松弛特性的2-羧酰胺基士的宁衍生物对脑突触体摄取胆碱的抑制作用。

Inhibition of brain synaptosomal uptake of choline by some 2-carboxamidostrychnine derivatives with muscle-relaxant properties.

作者信息

Eckernäs S A, Bohlin L, Sahlström L

出版信息

Acta Pharmacol Toxicol (Copenh). 1980 Aug;47(2):81-3. doi: 10.1111/j.1600-0773.1980.tb01844.x.

DOI:10.1111/j.1600-0773.1980.tb01844.x

Abstract

Some 2-carboxamido derivatives of strychnine with a peripheral muscle-relaxant effect in vivo and in vitro were tested for their ability to inhibit choline (Ch) uptake into mouse brain synaptosomes. A non-competitive inhibition of the high affinity Ch uptake by strychnine and some of its derivatives was observed.

摘要

对士的宁的一些在体内和体外具有外周肌肉松弛作用的2-甲酰胺基衍生物，测试了它们抑制胆碱（Ch）摄入小鼠脑突触体的能力。观察到士的宁及其一些衍生物对高亲和力胆碱摄入有非竞争性抑制作用。