Alate A D, Khandalekar D D, Amonkar A J, Adwankar M K, Sahasrabudhe M B
Biomedicine. 1978 Oct;28(5):270-3.
A new anti-cancer drug, code named GCE pending chemical characterization, has been isolated from a plant Gymnosporia rothiana, Laws. In addition to exhibiting good anti-cancer activities, GCE prolongs the "S" phase of cell cycle. This property has been exploited in evolving a new combination chemotherapy schedule with "S" phase sensitive drugs. Cures in L1210 bearing mice have been observed by administering GCE 2 hours prior to administration of "S" phase sensitive drug such as cytosine arabinoside (Ara-C), hydroxyurea (HU) or 5 fluorouracil (5FU).
一种新的抗癌药物，在完成化学特性鉴定之前代号为GCE，已从一种名为罗氏裸实属（Gymnosporia rothiana, Laws.）的植物中分离出来。除了具有良好的抗癌活性外，GCE还能延长细胞周期的“S”期。这一特性已被用于制定一种新的联合化疗方案，使用对“S”期敏感的药物。通过在给予“S”期敏感药物如阿糖胞苷（Ara-C）、羟基脲（HU）或5-氟尿嘧啶（5FU）前2小时给予GCE，已观察到携带L1210肿瘤的小鼠被治愈。
