Hollander D
Am J Physiol. 1980 Sep;239(3):G210-4. doi: 10.1152/ajpgi.1980.239.3.G210.
Absorption of [3H]retinol into lymph and bile was studied in unanesthetized rats with cannulated thoracic and common bile ducts. Retinol in a micellar solution was infused into the duodenum. Absorption of retinol into lymph increased when the infusate's taurocholate concentration was increased to 10 mM, when the hydrogen ion concentration was increased, or when octanoic acid was added to the infusate. Absorption of retinol into lymph decreased when the taurocholate concentration was decreased to 5 mM or when long-chain unsaturated fatty acids or retinoic acid were added to the duodenal infusate. Retinol absorption into bile increased following additions of linoleic and arachidonic acids to the infusate, but absorption did not change following modifications of the infusate's taurocholate concentration or pH. These experiments, which demonstrate that intraluminal factors do modify the extrusion of retinol into bile and lymph, enhance our overall understanding of the process of absorption of this lipid nutrient.
在胸导管和胆总管插管的未麻醉大鼠中研究了[3H]视黄醇向淋巴液和胆汁中的吸收情况。将处于胶束溶液中的视黄醇注入十二指肠。当注入液中牛磺胆酸盐浓度增加至10 mM、氢离子浓度增加或向注入液中添加辛酸时，视黄醇向淋巴液中的吸收增加。当牛磺胆酸盐浓度降至5 mM或向十二指肠注入液中添加长链不饱和脂肪酸或视黄酸时，视黄醇向淋巴液中的吸收减少。向注入液中添加亚油酸和花生四烯酸后，视黄醇向胆汁中的吸收增加，但改变注入液中牛磺胆酸盐浓度或pH值后，吸收没有变化。这些实验表明腔内因素确实会改变视黄醇向胆汁和淋巴液中的排出，增强了我们对这种脂质营养素吸收过程的整体理解。
