Kettelhut I C, Foss M C, Migliorini R H
Am J Physiol. 1980 Nov;239(5):R437-44. doi: 10.1152/ajpregu.1980.239.5.R437.
Glucose homeostasis in a carnivorous (cat) and in an omnivorous (rat) animal fed a high-protein, low-carbohydrate (HP) diet followed a pattern similar to that previously found in carnivorous birds [Am. J. Physiol. 234 (Regulatory Integrative Comp. Physiol. 3): R115-R121, 1978]. Thus, compared to controls given carbohydrate-rich (HC) diets. HP-fed animals had, in the fed state, lower levels of blood sugar, lower concentrations of liver glycogen, and a tendency to reduced body glucose mass. During fasting, their liver glycogen was little mobilized and their glycemia remained remarkably constant. Accordingly, their body glucose mass remained unchanged. Gluconeogenic capacity, already high in the fed state, was not further activated by fasting. Phosphoenolpyruvate carboxykinase activity actually decreased in rat liver cytosol, remaining unchanged in cat liver cytosol and mitochondria. [3H]glucose turnover studies revealed that in HP-fed cats and rats glucose replacement rates in the fed state were as high as in HC-fed animals and that the resistance of their glycemia to fasting depended on the high gluconeogenic capacity and not on a more efficient reduction of glucose utilization.
给肉食性动物（猫）和杂食性动物（大鼠）喂食高蛋白、低碳水化合物（HP）饮食后，其葡萄糖稳态呈现出与先前在肉食性鸟类中发现的模式相似的情况[《美国生理学杂志》234卷（调节整合与比较生理学3）：R115 - R121，1978年]。因此，与喂食富含碳水化合物（HC）饮食的对照组相比，喂食HP饮食的动物在进食状态下血糖水平较低，肝糖原浓度较低，且身体葡萄糖总量有降低的趋势。在禁食期间，它们的肝糖原很少被动员，血糖水平保持相当稳定。相应地，它们的身体葡萄糖总量保持不变。在进食状态下就已经很高的糖异生能力，在禁食时并未进一步激活。磷酸烯醇式丙酮酸羧激酶活性在大鼠肝细胞溶胶中实际上有所下降，在猫肝细胞溶胶和线粒体中保持不变。[³H]葡萄糖周转研究表明，在喂食HP饮食的猫和大鼠中，进食状态下的葡萄糖替代率与喂食HC饮食的动物一样高，并且它们的血糖对禁食的抵抗力取决于高糖异生能力，而不是更有效地降低葡萄糖利用率。
