通过拮抗剂谷氨酸二乙酯和D-α-氨基己二酸对兴奋性氨基酸进行排序。

Ranking of excitatory amino acids by the antagonists glutamic acid diethylester and D-alpha-aminoadipic acid.

作者信息

Hicks T P, Hall J G, McLennan H

出版信息

Can J Physiol Pharmacol. 1978 Dec;56(6):901-7. doi: 10.1139/y78-143.

Abstract

A separation of the excitatory actions of the amino acids upon thalamic neurones of rats anaesthetized with urethane has been accomplished through the use of two antagonists. It has been possible to rank the excitatory compounds in their order of susceptibility to D-alpha-aminoadipic acid (DalphaAA) and L-glutamic acid diethylester (GDEE). The observation that the ranking orders of the excitants differ for these two antagonists permits an analysis of the types of receptors with which the amino acid excitants react. The results support the proposition that more than one neuronal receptor sensitive to the amino acids exists.

摘要

通过使用两种拮抗剂，已实现对用乌拉坦麻醉的大鼠丘脑神经元上氨基酸兴奋性作用的分离。已能够按照对D-α-氨基己二酸（DalphaAA）和L-谷氨酸二乙酯（GDEE）的敏感顺序对兴奋性化合物进行排序。这两种拮抗剂的兴奋性物质排序顺序不同这一观察结果，允许对氨基酸兴奋性物质所反应的受体类型进行分析。结果支持存在不止一种对氨基酸敏感的神经元受体这一观点。