Christlieb I Y, Clark R E
Arch Surg. 1980 Nov;115(11):1339-43. doi: 10.1001/archsurg.1980.01380110073011.
We sought to determine the relative protective effects of an intracellular-like, calcium-bearing, crystalloid solution (ICS) and a calcium-free, extracellular-like solution (ECS). Both solutions were similar in concentrations of potassium ions (25 to 26 mEq/L), in pH (7.7 to 7.8), and in osmolarity (340 to 360 mOsm/L). Normothermia was used to obviate masking the true effects of the solutions with the independent effects of hypothermia. Fifty-seven dogs were placed on cardiopulmonary bypass and had global myocardial ischemia for one hour. Continuous infusions and bolus injections into the aortic root of control solutions (n = 24), ECS (n = 15), and ICS (n = 16) were used. Two-hour postischemic ventricular performance was superior for ICS in comparison with ECS or control solutions regardless of administration mode. The multidose mode gave improved results with control and ECS groups. The use of an ICS yields improved postischemic performance in normothermic dog hearts.
我们试图确定一种类似细胞内、含钙的晶体溶液（ICS）和一种无钙、类似细胞外的溶液（ECS）的相对保护作用。两种溶液在钾离子浓度（25至26 mEq/L）、pH值（7.7至7.8）和渗透压（340至360 mOsm/L）方面相似。采用正常体温以避免低温的独立作用掩盖溶液的真实效果。57只狗接受体外循环并经历一小时的全心肌缺血。使用向主动脉根部持续输注和推注对照溶液（n = 24）、ECS（n = 15）和ICS（n = 16）。无论给药方式如何，缺血后两小时，ICS组的心室功能均优于ECS组或对照溶液组。多剂量模式在对照组和ECS组中产生了更好的结果。在正常体温的犬心脏中，使用ICS可改善缺血后的心脏功能。
