Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system.

The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration. The compounds tested were 7-N-phenyl-, 7-N-(p-aminophenyl)-, 7-N-(p-hydroxyphenyl)- and 7-N-(p-chlorophenyl)-mitomycin C. The maximum increases in life span (ILSmax) obtained were 124, 169, > 386 and 112%, respectively, that with mitomycin C being 104%. 7-N-(p-Hydroxyphenyl)-mitomycin C showed a higher ILS% than its ortho and meta isomers. Thus, 7-N-(p-hydroxyphenyl)-mitomycin C was the most effective of these compounds.