Khan M M, Patterson G C, O'Kane H O, Adgey A A
Br Heart J. 1980 Nov;44(5):570-6. doi: 10.1136/hrt.44.5.570.
Four patients with rupture of the interventricular septum after myocardial infarction are described. This condition carries a grave prognosis. Surgical repair of the septum is almost always urgently required if the left-to-right shunt is large (QP/WS > 3). Results are better if surgery can be deferred for six weeks to allow the infarcted area to heal and the tissues to be come firmer. This delay may be achieved by using a combination of agents to reduce afterload and to exert a positive inotropic effect. The timing of surgical intervention was an important factor in the survival of three of the four patients.
本文描述了4例心肌梗死后室间隔破裂的患者。这种情况预后严重。如果左向右分流较大（QP/WS>3），几乎总是急需进行室间隔手术修复。如果手术能推迟六周，以使梗死区域愈合且组织变得更坚实，则效果会更好。可通过联合使用降低后负荷和发挥正性肌力作用的药物来实现这种延迟。手术干预的时机是这4例患者中3例存活的重要因素。
