Robinson B F, Dobbs R J, Kelsey C R
Br J Clin Pharmacol. 1980 Nov;10(5):433-8. doi: 10.1111/j.1365-2125.1980.tb01784.x.
1 The effect of nifedipine on peripheral blood vessels has been studied in man. 2 Nifedipine induced dilatation of the forearm resistance vessels when given either by local intra-arterial infusion or sublingually (10 mg). 3 Local infusion of the drug did not relax hand veins preconstricted by infusion of noradrenaline and neither local infusion nor sublingual administration prevented constriction mediated by the sympathetic nervous system. Nifedipine was, however, a potent inhibitor of hand vein contractions induced by high concentrations of potassium provided that the noradrenergic component of the response was suppressed by simultaneous infusion of phentolamine. 4 Sublingual nifedipine (10 mg) did not dilate the elbow collateral arteries. 5 The effects of nifedipine on peripheral blood vessels are similar, but not identical, to those of verapamil. The pattern of action, with dilatation of resistance vessels but not capacitance, resembles that of hydralazine rather than glyceryl trinitrate and this suggest that nifedipine may prove useful in the treatment of hypertension.
硝苯地平对人体外周血管的作用已得到研究。
当通过局部动脉内输注或舌下含服（10毫克）给予硝苯地平时，它会引起前臂阻力血管扩张。
局部输注该药物不会使因去甲肾上腺素输注而预先收缩的手部静脉松弛，并且局部输注和舌下给药均不能阻止交感神经系统介导的收缩。然而，如果通过同时输注酚妥拉明抑制反应中的去甲肾上腺素能成分，硝苯地平是高浓度钾诱导的手部静脉收缩的有效抑制剂。
舌下含服硝苯地平（10毫克）不会使肘部侧支动脉扩张。
硝苯地平对外周血管的作用与维拉帕米相似，但不完全相同。其作用模式为阻力血管扩张而容量血管不扩张，类似于肼屈嗪而非硝酸甘油，这表明硝苯地平可能在高血压治疗中有用。
