Anderson W, Harthill J E, James W B, Montgomery D
Br J Radiol. 1980 Dec;53(636):1150-9. doi: 10.1259/0007-1285-53-636-1150.
Physical properties relevant to upper gastrointestinal radiology have been compared for five barium sulphate preparations and related to radiographic results. Evaluation of particles (size and stability) and whole suspension (dispersibility and fluidity) resulted in ranking of the preparations generally in accord with that based on radiological experience in double contrast examinations of the stomach. Experiments with extirpated pig stomach revealed a tendency for large particles in a low viscosity barium sulphate suspension to settle in mucosal grooves. This is believed to contribute to good radiographic definition of both the areae gastricae and small lesions. Particle size is therefore important and susceptibility to flocculation, a possible cause of random change in size during use, was assessed by measuring particle electrophoretic mobility under varying conditions; quantitative differences in suspension flow and dispersibility were also demonstrated. Fluidity and dispersibility together with rapid sedimentation of suitably sized particles resistant to flocculation underlie the successful use of low viscosity high density barium sulphate suspensions.
对五种硫酸钡制剂的与上消化道放射学相关的物理性质进行了比较，并将其与放射学结果相关联。对颗粒（大小和稳定性）以及整个悬浮液（分散性和流动性）的评估得出了这些制剂的排名，总体上与基于胃部双重对比检查的放射学经验的排名一致。对切除的猪胃进行的实验表明，低粘度硫酸钡悬浮液中的大颗粒有沉积在粘膜沟中的趋势。据信这有助于胃小区和小病变的良好放射学清晰度。因此，颗粒大小很重要，并且通过在不同条件下测量颗粒电泳迁移率来评估絮凝敏感性，这是使用过程中颗粒大小随机变化的一个可能原因；还证明了悬浮液流动和分散性的定量差异。流动性和分散性以及大小合适且抗絮凝的颗粒的快速沉降是成功使用低粘度高密度硫酸钡悬浮液的基础。
