用乙酰唑胺和螺内酯治疗难治性充血性心力衰竭及正常血钾性低氯性碱中毒。
Treatment of refractory congestive heart failure and normokalemic hypochloremic alkalosis with acetazolamide and spironolactone.
作者信息
Khan M I
出版信息
Can Med Assoc J. 1980 Nov 8;123(9):883-7.
Abstract
Combination therapy with a loop diuretic and an aldosterone antagonist can produce normokalemic hypochloremic alkalosis, a complication not previously documented in the literature. This report describes 74 patients who had severe congestive heart failure treated with a combination of furosemide and spironolactone in whom this complication developed. Acetazolamide corrected the metabolic abnormality. The combination of furosemide and spironolactone with intermittent courses of acetazolamide was very effective in the treatment of severe congestive heart failure complicated by normokalemic hypochloremic alkalosis.
摘要
联用袢利尿剂和醛固酮拮抗剂进行治疗可导致正常血钾性低氯性碱中毒，这是一种此前文献中未记载的并发症。本报告描述了74例重度充血性心力衰竭患者，他们接受了呋塞米和螺内酯联合治疗，并发了该并发症。乙酰唑胺纠正了代谢异常。呋塞米、螺内酯与间歇性使用乙酰唑胺联合，在治疗并发正常血钾性低氯性碱中毒的重度充血性心力衰竭方面非常有效。
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本文引用的文献
1
The effect of changes in concentration of cations on the electrocardiogram of the isolated perfused heart.阳离子浓度变化对离体灌注心脏心电图的影响。
Am Heart J. 1952 Jun;43(6):801-14. doi: 10.1016/0002-8703(52)90235-4.
2
Electrolyte equilibrium during mercurial diuresis.汞利尿期间的电解质平衡。
J Clin Invest. 1951 Oct;30(10):1089-1104. doi: 10.1172/JCI102529.
3
The role of electrolyte balance in the response to mercurial diuretics in congestive heart failure.电解质平衡在充血性心力衰竭中对汞利尿剂反应中的作用。
Bull New Engl Med Cent. 1950 Dec;12(6):213-8.
4
Management of congestive heart failure; management designed to avoid serious disturbances of electrolyte and water balance.充血性心力衰竭的管理；旨在避免电解质和水平衡严重紊乱的管理。
AMA Arch Intern Med. 1955 Mar;95(3):385-99. doi: 10.1001/archinte.1955.00250090023005.
5
BODY AND SERUM POTASSIUM IN LIVER DISEASE. I. RELATIONSHIP TO HEPATIC FUNCTION AND ASSOCIATED FACTORS.肝病患者体内及血清中的钾。I. 与肝功能及相关因素的关系
Gastroenterology. 1965 Feb;48:198-207.
6
THE CRITICAL ROLE OF CHLORIDE IN THE CORRECTION OF HYPOKALEMIC ALKALOSIS IN MAN.氯在纠正人体低钾性碱中毒中的关键作用。
Am J Med. 1965 Feb;38:172-89. doi: 10.1016/0002-9343(65)90172-5.
7
THIAZIDE DIURETICS.噻嗪类利尿剂
Annu Rev Med. 1964;15:149-66. doi: 10.1146/annurev.me.15.020164.001053.
8
Effect of high K, and low K quinindine on QRS duration and ventricular action potential.
Am J Physiol. 1962 Dec;203:1135-40. doi: 10.1152/ajplegacy.1962.203.6.1135.
9
The mechanism of action of mercurial and xanthine diuretics.
Ann N Y Acad Sci. 1958 Feb 3;71(4):344-54. doi: 10.1111/j.1749-6632.1958.tb46761.x.
10
Influence of potassium deprivation and adrenalectomy on potassium concentration of the myocardium.
Am J Physiol. 1955 Jun;181(3):550-2. doi: 10.1152/ajplegacy.1955.181.3.550.
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