地塞米松对大鼠诱导性体液自身免疫反应的抑制作用
Suppression of induced humoral autoimmune response by dexamethasone in rats.
作者信息
Makker S P
出版信息
Clin Exp Immunol. 1978 Dec;34(3):436-40.
The effect of dexamethasone on the humoral antibody response to sheep red blood cells (SRBC) and on the humoral autoantibody response to a renal tubular antigen was studied in rats. The Heymann model of autoimmune, immune complex-induced glomerulonephritis was employed for studying the autoimmune response. It was found that dexamethasone did not appear to have much effect on the humoral antibody response to SRBC (>0·05), but it had a pronounced effect on the humoral autoantibody response (<0·0001). These results may be interpreted to suggest that, in rats, the cellular events and the mechanism of humoral autoantibody response may be different from those involved in the generation of humoral antibody response to SRBC, because dexamethasone seems to have a pronounced effect on the former and very little on the latter.
在地塞米松对大鼠针对绵羊红细胞（SRBC）的体液抗体反应以及针对肾小管抗原的体液自身抗体反应的影响方面展开了研究。采用海曼自身免疫性、免疫复合物诱导的肾小球肾炎模型来研究自身免疫反应。结果发现，地塞米松对针对SRBC的体液抗体反应似乎没有太大影响（>0·05），但对体液自身抗体反应有显著影响（<0·0001）。这些结果或许可以解释为，在大鼠中，细胞事件以及体液自身抗体反应的机制可能与针对SRBC的体液抗体反应产生过程中所涉及的不同，因为地塞米松似乎对前者有显著影响，而对后者影响极小。
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