Blackburn G R, Andrews J P, Rao K V, Sorof S
Cancer Res. 1980 Dec;40(12):4688-93.
This report describes an early and direct action of oncogenic agents and its apparent consequences. Chemical carcinogen has been found to interact principally with a specific polypeptide in livers of normal rats. Short-term ingestion of carcinogen causes marked reductions in the concentrations of both the carcinogen:polypeptide complex and the polypeptide itself. This action and its consequences are unique in several ways. (a) Chemical carcinogen is directly involved in the event. (b) Three kinds of liver carcinogens act in this way: the aromatic amide, N-2-fluorenylacetamide (2-acetylaminofluorene); the aminoazo dye, 3'-methyl-4-dimethylaminoazobenzene; and the amino acid analog, ethionine. (c) The interaction of chemical carcinogen with a specific polypeptide is involved. (d) Both the carcinogen:polypeptide complex and the polypeptide itself undergo marked reductions in concentration during hepatocarcinogenesis by the three types of carcinogens. (e) The consequences of the interaction are sensitive indicators unusually early during liver carcinogenesis. (f) The target polypeptide has a molecular weight of 14,700, similar to those of known polypeptide growth regulators.
本报告描述了致癌剂的早期直接作用及其明显后果。已发现化学致癌物主要与正常大鼠肝脏中的一种特定多肽相互作用。短期摄入致癌物会导致致癌物：多肽复合物和多肽本身的浓度显著降低。这一作用及其后果在几个方面是独特的。(a)化学致癌物直接参与该事件。(b)三种肝脏致癌物以这种方式起作用：芳香酰胺，N-2-芴基乙酰胺(2-乙酰氨基芴)；氨基偶氮染料，3'-甲基-4-二甲基氨基偶氮苯；以及氨基酸类似物，乙硫氨酸。(c)涉及化学致癌物与特定多肽的相互作用。(d)在三种致癌物诱发肝癌的过程中，致癌物：多肽复合物和多肽本身的浓度均显著降低。(e)相互作用的后果是肝癌发生过程中异常早期的敏感指标。(f)靶多肽的分子量为14,700，与已知的多肽生长调节剂相似。
