Morrison J C, Propst M G, Blake P G
Clin Perinatol. 1980 Sep;7(2):273-84.
It is evident that patients with sickle cell disease are now in an era when they can safely complete a pregnancy with a reasonable expectation of a good outcome for both the mother and baby. Although there are vast disagreements as to which techniques (both diagnostic and therapeutic) to employ, the use of individualized methods in various geographic areas will yield the best result. To conclusively answer the questions raised in this article, a large multi-center collaborative study must be performed. If randomized treatment regimens of "transfusion versus no transfusion" were carried out in such a study, the true risk of both approaches could be assessed. Moreover, with adequate follow-up studies many of the risks of each type of treatment could be evaluated. Only through such a large study will these controversies be resolved.
显然，镰状细胞病患者如今正处于一个能够安全完成妊娠的时代，且有理由期望母婴双方都能有良好的结局。尽管对于采用何种技术（包括诊断和治疗技术）存在巨大分歧，但在不同地理区域采用个体化方法将产生最佳效果。为了最终回答本文提出的问题，必须开展一项大型多中心合作研究。如果在这样的研究中实施“输血与不输血”的随机治疗方案，就可以评估这两种方法的真正风险。此外，通过充分的随访研究，可以评估每种治疗类型的许多风险。只有通过这样的大型研究，这些争议才能得到解决。
